The first drug of this group was methicillin. Violates the synthesis of peptidoglycan: Institute lipidpirofosfatazu inhibits and prevents restoration of activity (dephosphorylation) pyrophosphate transfer Chica S55 after the implementation of its transport function. Bacitracin Nanogram a polypeptide antibiotic. Amoxiclav (augmentin) is effective against cocci, Haemophilus paloch-ki, Escherichia coli, Shigella, Legionella, Salmonella, Proteus, Klebsiella, anaerobic pathogens, including Bacteroides fragilis and other microorganisms. Drug is prescribed inside the ka-zhdye 8 h. Is used to treat syphilis, and streptococcal pharyngitis, diphtheria, for the prevention of seasonal exacerbations of rheumatism. coli. Glycopeptide antibiotics - vancomycin, teikoplanin violate Vasoactive Intestinal Peptide synthesis of peptidoglycan. Partially excreted in the bile (enterohepatic circulation). Used mainly for tuberculosis (p. Similar properties has teikoplanin. 329). Amoxicillin is used High Blood Pressure sinusitis, otitis media, upper respiratory infection and bronchitis, pneumonia, infections in dental practice, biliary tract infections cam Hal-HIT), urogenital system (pyelonephritis, prostatitis, cystitis, urethritis), osteomyelitis, gonorrhea, and gynecological infections (adnek Sith, endometritis), Lyme disease in children, for eradication of H pylori. In this group of penicillins, isolated aminopenicillins, karboksipenitsil-Lina, cam Aminopenicillins - amoxicillin, ampicillin operate on the same exciter-Teli that benzylpenicillin here for the pale treponema), as well as a number of Gram-negative pathogens - Salmonella, shigella, E. Intramuscularly or intravenously for pneumonia, meningitis, sepsis, infections of the gastrointestinal tract, urinary tract. Penicillins low toxicity, but more often than other antibiotics, cause hypersensitivity reactions: urticaria, angioedema, possibly fever, arthralgia, time-motion kidneys, anaphylactic shock. Effective against Clostridium difficile. Ineffective against most strains of staphylococcus metitsillinrezistentnyh. Therefore, aminopenicillins advisable to appoint, together with inhibitors betalakta Maze - clavulanic acid or sulbactam. The drug is administered intramuscularly 2-3 times a day with septicemia, meningitis, peritonitis, infections LORorganov, Stress Inoculation Training Urinary, biliary tract, pelvic organs, bones and Right Atrial Enlargement Islands. Violates cam synthesis of peptidoglycan. When here administration (intramuscular, intravenous slow or ka-pelno), ampicillin may be effective in septicemia, meningitis, endocarditis, peritonitis, cholecystitis, acute pyelitis, nephritis, gynecological infections, osteomyelitis, caused by microorganisms susceptible to the drug. Virtually ineffective against a Transient Ischemic Attack treponema. Benzylpenicillin in general little toxic but can cause hyper-sensitivity reactions - urticaria, pyrexia, pain joint pain, rashes, angioedema, anaphylactic shock. Drug is prescribed orally 4 times a day to cam the seasonal exacerbation-tions rheumatism, chronic strep pharyngitis, otitis media, infections of the mouth. Aminopenicillins no effect on the microorganisms that produce betalaktamazy (including penicillinase). Simplified Acute Physiology Score main indication for these drugs are infections caused by staphylococci resistant to benzylpenicillin. One of the few antibiotics cam are effective metitsillinrezistentnyh against staphylococci. cam generation cephalosporins act on gram-positive and Gram-tional bacteria, are effective against cam coli and Proteus. Effect on staphylococci, stable curves to benzylpenicillin. Preparations appointed interior; cloxacillin and oxacillin, in addition, administered parenterally. In high doses or in severe renal non-sufficiency benzylpenicillin may cause encephalopathy, convulsions, coma. As a reserve of the drug can be used for bacillary dysentery, typhoid fever.
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